Deadlock detection for actor-based coroutines

The actor-based language studied in this paper features asynchronous method calls and supports coroutines which allow for the cooperative scheduling of the method invocations belonging to an actor. We model the local behavior of an actor as a well-structured transition system by means of predicate abstraction and derive the decidability of the occurrence of deadlocks caused by the coroutine mode of method execution

A Formal, Resource Consumption-Preserving Translation of Actors to Haskell

We present a formal translation of an actor-based language with cooperative scheduling to the functional language Haskell. The translation is proven correct with respect to a formal semantics of the source language and a high-level operational semantics of the target, i.e. a subset of Haskell. The main correctness theorem is expressed in terms of a simulation relation between the operational semantics of actor programs and their translation. This allows us to then prove that the resource consumption is preserved over this translation, as we establish an equivalence of the cost of the original and Haskell-translated execution traces.Comment: Pre-proceedings paper presented at the 26th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2016), Edinburgh, Scotland UK, 6-8 September 2016 (arXiv:1608.02534

Agent Programming with Declarative Goals

A long and lasting problem in agent research has been to close the gap between agent logics and agent programming frameworks. The main reason for this problem of establishing a link between agent logics and agent programming frameworks is identified and explained by the fact that agent programming frameworks have not incorporated the concept of a `declarative goal'. Instead, such frameworks have focused mainly on plans or `goals-to-do' instead of the end goals to be realised which are also called `goals-to-be'. In this paper, a new programming language called GOAL is introduced which incorporates such declarative goals. The notion of a `commitment strategy' - one of the main theoretical insights due to agent logics, which explains the relation between beliefs and goals - is used to construct a computational semantics for GOAL. Finally, a proof theory for proving properties of GOAL agents is introduced. Thus, we offer a complete theory of agent programming in the sense that our theory provides both for a programming framework and a programming logic for such agents. An example program is proven correct by using this programming logic

Abstract Analysis of Universal Properties for tccp

[EN] The Timed Concurrent Constraint Language (tccp) is a time extension of the concurrent constraint paradigm of Saraswat. tccp was defined to model reactive systems, where infinite behaviors arise naturally. In previous works, a semantic framework and abstract diagnosis method for the language has been defined. On the basis of that semantic framework, this paper proposes an abstract semantics that, together with a widening operator, is suitable for the definition of different analyses for tccp programs. The abstract semantics is correct and can be represented as a finite graph where each node represents a hypothetical computational step of the program containing approximated information for the variables. The widening operator allows us to guarantee the convergence of the abstract fixpoint computation.This work has been supported by the Andalusian Excellence Project P11-TIC7659. This work has been partially supported by the EU (FEDER) and the Spanish MINECO under grant TIN 2013-45732-C4-1-P (DAMAS) and by Generalitat Valenciana PROMETEOII/2015/013Comini, M.; Gallardo Melgarejo, MDM.; Titolo, L.; Villanueva, A. (2015). Abstract Analysis of Universal Properties for tccp. Lecture Notes in Computer Science. 163-178. https://doi.org/10.1007/978-3-319-27436-2_10S163178Alpuente, M., Gallardo, M.M., Pimentel, E., Villanueva, A.: A semantic framework for the abstract model checking of tccp programs. Theor. Comput. Sci. 346(1), 58–95 (2005)Bagnara, R., Hill, P.M., Ricci, E., Zaffanella, E.: Precise widening operators for convex polyhedra. Sci Comput. Program. 58(1–2), 28–56 (2005)Comini, M., Titolo, L., Villanueva, A.: Abstract diagnosis for timed concurrent constraint programs. Theor. Pract. Log. Program. 11(4–5), 487–502 (2011)Comini, M., Titolo, L., Villanueva, A.: A condensed goal-independent bottom-up fixpoint modeling the behavior of tccp. Technical report, DSIC, Universitat Politècnica de València (2013). http://riunet.upv.es/handle/10251/34328Cousot, P., Cousot, R.: Abstract Interpretation: a unified lattice model for static analysis of programs by construction or approximation of fixpoints. In: Proceedings of the 4th ACM SIGACT-SIGPLAN Symposium on Principles of Programming Languages, Los Angeles, California, January 17–19, pp. 238–252. ACM Press, New York (1977)de Boer, F.S., Gabbrielli, M., Meo, M.C.: A timed concurrent constraint language. Inf. Comput. 161(1), 45–83 (2000)Falaschi, M. Gabbrielli, M., Marriott, K., Palamidessi, C.: Compositional analysis for concurrent constraint programming. In: Proceedings of the Eighth Annual IEEE Symposium on Logic in Computer Science, pp. 210–221. IEEE Computer Society Press, Los Alamitos (1993)Falaschi, M., Olarte, C., Palamidessi, C.: Abstract interpretation of temporal concurrent constraint programs. Theor. Pract. Log. Program. (TPLP) 15(3), 312–357 (2015)Falaschi, M., Villanueva, A.: Automatic verification of timed concurrent constraint programs. Theor. Pract. Log. Program. 6(3), 265–300 (2006)Saraswat, V.A.: Concurrent Constraint Programming. The MIT Press, Cambridge (1993)Zaffanella, E., Giacobazzi, R., Levi, G.: Abstracting synchronization in concurrent constraint programming. J. Funct. Log. Program. 6, 1997 (1997

On the nature of symbolic execution

In this paper, we provide a formal definition of symbolic execution in terms of a symbolic transition system and prove its correctness with respect to an operational semantics which models the execution on concrete values. We first introduce such a formal model for a basic programming language with a statically fixed number of programming variables. This model is extended to a programming language with recursive procedures which are called by a call-by-value parameter mechanism. Finally, we show how to extend this latter model of symbolic execution to arrays and object-oriented languages which feature dynamically allocated variables

A program analysis framework for tccp based on abstract interpretation

[EN] The timed concurrent constraint language (tccp) is a timed extension of the concurrent constraint paradigm. tccp was defined to model reactive systems, where infinite behaviors arise naturally. In previous works, a semantic framework and abstract diagnosis method for the language have been defined. On the basis of that semantic framework, this paper proposes an abstract semantics that, together with a widening operator, is suitable for the definition of different analyses for tccp programs. The abstract semantics is correct and can be represented as a finite graph where each node represents a hypothetical (abstract) computational step of the program. The widening operator allows us to guarantee the convergence of the abstract fixpoint computation.This author has been supported by the Andalusian Excellence Project P11-TIC-7659. This work has been partially supported by the EU (FEDER) and the Spanish MINECO under grants TIN 2015-69175-C4-1-R and TIN 2013-45732-C4-1-P and by Generalitat Valenciana PROMETEOII/2015/013Comini, M.; Gallardo, M.; Titolo, L.; Villanueva, A. (2017). A program analysis framework for tccp based on abstract interpretation. Formal Aspects of Computing. 29(3):531-557. https://doi.org/10.1007/s00165-016-0409-8S531557293Alpuente M, Gallardo MM, Pimentel E, Villanueva A (2006) A semantic framework for the abstract model checking of tccp programs. Theor Comput Scie 346(1): 58–95Bagnara R, Hill PM., Ricci E, Zaffanella E (2005) Precise widening operators for convex polyhedra. Sci Comput Program 58(1–2):28–56Cousot P, Cousot R (1977) Abstract interpretation: a unified lattice model for static analysis of programs by construction or approximation of fixpoints. In: Proceedings of the 4th ACM SIGACT-SIGPLAN symposium on principles of programming languages, Los Angeles, California, January 17–19. ACM Press, New York, pp 238–252Clarke EM, Grumberg O, Jha S, Lu Y, Veith H (2000) Counterexample-guided abstraction refinement. In: CAV, Lecture Notes in Computer Science, vol 1855. Springer, pp 154–169Comini M, Gallardo MM, Titolo L, Villanueva A (2015) Abstract Analysis of Universal Properties for tccp. In: Falaschi M (ed) Logic-based Program Synthesis and Transformation, 25th International Symposium, LOPSTR 2015. Revised Selected Papers, Lecture Notes in Computer Science, vol 9527. Springer, pp 163–178Comini M, Titolo L, Villanueva A (2011) Abstract diagnosis for timed concurrent constraint programs. Theory Pract Logic Programm 11(4-5):487–502Comini M, Titolo L, Villanueva A (2013) A condensed goal-independent bottom-up fixpoint modeling the behavior of tccp. Technical report, DSIC, Universitat Politècnica de València. http://riunet.upv.es/handle/10251/34328de Boer FS, Gabbrielli M, Meo MC (2000) A timed concurrent constraint language. Inf Comput 161(1): 45–83Falaschi M, Gabbrielli M, Marriott K, Palamidessi C (1993) Compositional analysis for concurrent constraint programming. In: Proceedings of the eighth annual IEEE symposium on logic in computer science, Los Alamitos, CA, USA, IEEE Computer Society Press, pp 210–221Falaschi M, Olarte C, Palamidessi C (2015) Abstract interpretation of temporal concurrent constraint programs. Theory and Pract Logic Program (TPLP) 15(3): 312–357Falaschi M, Villanueva A (2006) Automatic verification of timed concurrent constraint programs. Theory Pract Logic Program 6(3): 265–300Gallardo MM, Merino P, Pimentel E (2002) Refinement of LTL formulas for abstract model checking. In: Static analysis, 9th international symposium, SAS 2002, Madrid, Spain, September 17–20, 2002, Proceedings, pp 395–410Saraswat VA (1993) Concurrent constraint programming. The MIT Press, CambridgeSaraswat VA, Rinard M, Panangaden P (1991) The semantic foundations of concurrent constraint programming. In: Proceedings of the 18th ACM SIGPLAN-SIGACT symposium on principles of programming languages. ACM, New York, pp 333–352Zaffanella E, Giacobazzi R, Levi G (1997) Abstracting synchronization in concurrent constraint programming. J Funct Logic Program (6

Cytokine Combination Therapy with Erythropoietin and Granulocyte Colony Stimulating Factor in a Porcine Model of Acute Myocardial Infarction

PurposeErythropoietin (EPO) and granulocyte colony stimulating factor (GCSF) have generated interest as novel therapies after myocardial infarction (MI), but the effect of combination therapy has not been studied in the large animal model. We investigated the impact of prolonged combination therapy with EPO and GCSF on cardiac function, infarct size, and vascular density after MI in a porcine model.MethodsMI was induced in pigs by a 90 min balloon occlusion of the left anterior descending coronary artery. 16 animals were treated with EPO+GCSF, or saline (control group). Cardiac function was assessed by echocardiography and pressure-volume measurements at baseline, 1 and 6 weeks post-MI. Histopathology was performed 6 weeks post-MI.ResultsAt week 6, EPO+GCSF therapy stabilized left ventricular ejection fraction, (41 ± 1% vs. 33 ± 1%, p < 0.01) and improved diastolic function compared to the control group. Histopathology revealed increased areas of viable myocardium and vascular density in the EPO+GCSF therapy, compared to the control. Despite these encouraging results, in a historical analysis comparing combination therapy with monotherapy with EPO or GCSF, there were no significant additive benefits in the LVEF and volumes overtime using the combination therapy.ConclusionOur findings indicate that EPO+GCSF combination therapy promotes stabilization of cardiac function after acute MI. However, combination therapy does not seem to be superior to monotherapy with either EPO or GCSF

Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype

INTRODUCTION: Esmirtazapine is evaluated as a novel drug for treatment of insomnia. PURPOSE: The present study was designed to assess residual effects of single and repeated doses of esmirtazapine 1.5 and 4.5 mg on actual driving in 32 healthy volunteers in a double-blind, placebo-controlled study. Treatment with single doses of zopiclone 7.5 mg was included as active control. METHODS: Treatments were administered in the evening. Driving performance was assessed in the morning, 11 h after drug intake, in a standardized on-the-road highway driving test. The primary study parameter was standard deviation of lateral position (SDLP), a measure of "weaving". All subjects were subjected to CYP2D6 phenotyping in order to distinguish poor metabolizers from extensive metabolizers of esmirtazapine. RESULTS: Overall, esmirtazapine 1.5 mg did not produce any clinically relevant change in SDLP after single and repeated dosing. Driving impairment, i.e., a rise in SDLP, did occur after a single-dose administration of esmirtazapine 4.5 mg but was resolved after repeated doses. Acute driving impairment was more pronounced after both doses of esmirtazapine in a select group of poor metabolizers (N = 7). A single-dose zopiclone 7.5 mg also increased SDLP as expected. CONCLUSION: It is concluded that single and repeated doses of 1.5 mg esmirtazapine are generally not associated with residual impairment. Single-dose administration of 4.5 mg esmirtazapine was associated with residual impairment that generally resolved after repeated administration. Exploratory analysis in a small group of poor CYP 2D6 metabolizers suggested that these subjects are more sensitive to the impairing effects of esmirtazapine on car driving